人类基因组计划(Human Genome Project)的目标之一就是要让研究者找出单个基因多个变体(亦即等位基因)与特定疾病之间的关联。
One of the goals of the Human Genome Project was to allow researchers to link versions of individual genes (known as alleles) with particular diseases.
其中HLA-DQA1等位基因的分布及其与疾病关联受到很大的关注。
Moreover, HLA-DQA1 allelic distribution and association with diseases should be paid great attention.
PV患者血清瘦素水平显著增高，并与HLA等位基因相关联，提示HLA等位基因和瘦素参与PV发病过程。
These results together suggest that HLA alleles are involved in modulating serum leptin levels and might be predisposition alleles for PV in the studied population.
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