对于这样的替代性方法，第一个疑问是从原则上说来其是否有效？

The first question to ask of such an approach is, could it work in principle?

youdao

假设他赢了—不过这还是个很大的疑问—他将成为五十年以来第一个获胜的英格兰人。

If he wins—and it's a big if —he'll be the first Englishman to win for fifty years.

《牛津词典》

孩子学好语言的第一个特征就是控制声音的升降，从而区分陈述和疑问。

One of the first features of language a child learns well is to control the rise and fall of the voice to make the difference between stating and questioning.

youdao

So the first parable that we have to look at is the one that without question instilled the most anxiety in Milton, and that's the parable of the talents from Matthew 25.

我们要看的第一个寓言,毫无疑问,就是关于弥尔顿最为焦虑的，问题的马修25中关于天资的寓言。

耶鲁公开课 - 弥尔顿课程节选