第一，川楝素以先易化后抑制的双相作用干扰神经递质释放，阻遏神经肌肉接头和中枢神经突触的突触传递。
The first is that by interfering with neurotransmitter release by causing an initial facilitation, TSN eventually blocks synaptic transmission at both the neuromuscular junction and central synapses.
而且，我们发现突触前灭活早老蛋白而突触后未灭活时改变了突触的短期可塑性和突触易化。
Moreover, we found that presynaptic but not postsynaptic inactivation of presenilins alters short-term plasticity and synaptic facilitation.
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