胰岛素受体前水平 1979年Tager等发现突变胰岛素(mutant insulin)引起糖尿病于B莲上第25个氨基酸(苯丙氨酸)为亮氨酸所替代而失效后又发现B链上第24个氨基酸(苯丙氨酸)亦为丝氨酸所替代、A链上...
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有这种基因突变的人身体对胰岛素的需要非常小,所以不得糖尿病。
The mutation seems to prevent diabetes by allowing people to get by on very low levels of insulin, Long says.
侏儒鼠拥有相同的GHR突变有着癌症发病率低,增加胰岛素敏感性预防糖尿病,并且延长寿命的特点。
Dwarf mice with the same GHR mutation have low cancer rates, increased insulin sensitivity that protects against diabetes, and extended life span.
结论:胰岛素基因启动子突变可能不是中国人2型糖尿病的重要遗传因素。
Therefore mutation of insulin gene promoter might not be a major genetic factor for type 2 diabetes mellitus in Chinese patients.
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