其中的教训是，无法应对结构性突变的预测方法，会几乎无限次地失效。

The lesson is that a forecasting technique that cannot deal with structural breaks is a forecasting technique that can misfire almost indefinitely.

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但这些变化并不像成功的基因突变一样，能够永久地遗传下去，实际上它们往往在一两代的时间里就会消失。

But those changes are not passed on indefinitely, like a successful genetic mutation would be. Instead, they are wiped out over a generation or two.

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傅的团队想要更可控地研究这种基因突变的效果，所以他们改造出一种拥有同种基因变化的老鼠。

Fu's group wanted to study the effect of the mutation in a more controlled way, so they created a strain of mice with the same genetic change.

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