损伤后1周显示神经元减少，可有空泡形成。
The decreased number of neuron and cavitations were observed 1 week later.
在基底层有上皮细胞的空泡形成或溶解，并伴淋巴细胞浸润。
There is vacuolization and dissolution of epidermal cells along the basal layer, along with lymphocytes.
结论环己酮草酰二腙可诱导大鼠脑白质脱髓鞘、空泡样变，呈时间剂量相关性，随着时间延长和累积剂量增加，细胞凋亡及空泡形成增多；
It was related to the dosage and time. Along with the time extension and the cuprizone dosage increasement, the cell apoptosis increased and the demyelination aggravated.
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