药物在连续恒速给药(如静脉输注)或分次恒量给药的过程中,血药浓度会逐渐增高, 经4~5个半衰期可达稳定而有效的血药浓度,此时药物吸收速度与消除速度达到平衡,血药浓度相对稳定在一定水平,这时的血药浓度称为稳态血药浓度,也称坪值。
... 释义:元素浓度校正曲线 element concentration calibration curve 稳态血药浓度-时间曲线下面积 AUCss 血药浓度-时间曲线下面积 AUC ...
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Furthermore, merged the five drug data and established the model to predict the five drugs’steady plasma-drug concentration predictive models.
将五种药物的数据资料合并,建立可预测这五种药物的稳态血药浓度的模型。
参考来源 - 群体药物动力学的径向基函数神经网络模型及其智能专家系统研究·2,447,543篇论文数据,部分数据来源于NoteExpress
稳态血药浓度峰值和谷值与体重剂量呈正相关;
There is positive correlation between peak and trough steady-state concentration and the body weight doses.
目的研究氯氮平不同剂量时稳态血药浓度与临床效应的关系。
Objective the study investigated the relationship between serum level and clinical response to clozapine in different dose for treating schizophrenic patients.
结果:稳态血药浓度与给药剂量、给药时间、是否联合用药等有着密切的关系。
Results: There is a close relation between the drug serum concentration in stable state and the administration dosage, interval and weather associated with other epileptic drugs.
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