在此基础上,20世纪90年代产生了更为完全的第二代人源化抗体,即CDR移植抗体(CDR-grafted antibody),它将鼠单抗的互补决定区(CDR区)移植到人单抗的骨架上,仅保留了3个CDR是鼠源性的,人源性可达90%以上。
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移植体抗宿主反应疾病 graft versus host disease ; GVHD
移植体对抗宿主疾病 graft-versus-host disease
移植物体抗宿主疾病 graft versus host disease
由于抗体不相容,他不能接受心脏移植。
Because of an antibody incompatibility, he is unable to receive a transplant.
由于抗体不相容,他不能接受心脏移植。
Because of an antibody incompatibility, he is unable to receive a transplant. No matter.
前不久,人们开始重新关注于抗体诱导在肝移植方面的应用,将其作为消除或减少一种或多种免疫抑制药物的治疗方案的一部分。
More recently there has been renewed interest in antibody induction in liver transplantation as part of a strategy to eliminate or reduce one or more immunosuppressive agents.
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