有时候可以根据问题域的理论知识预测复杂性，但是在编写代码时，又会产生新的约束和机会，这些实际上是无法预测的。
You can sometimes predict complexity based on speculative knowledge of the problem domain, but writing code creates new constraints and opportunities that are virtually impossible to predict.
通过将系统知识限制在单个层，可以限制整个系统的复杂性，促进了底层的独立性。
By restricting knowledge of the system to a single layer, a boundary is placed on the overall system complexity, promoting substrate independence.
现在我们有足够的工具和系统生物学知识来揭示这些疾病完全的复杂性。
We now have enough tools and knowledge of systems biology to take on the total complexity of these diseases.
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