与附近目标酶的活性位点不可逆的结合。
Blocks the action of target enzymes by binding nearly irreversibly to their active site.
另一个例证是，葛兰素史克公司的研究人员最近描述了一种以iia型拓扑异构酶为作用目标的新的抗菌剂。
Another example is that of researchers at GlaxoSmithKline who recently described a novel class of antibacterial agents that target type IIA topoisomerases.
研究人员说，尽管这项技术可以被应用于多种蛋白质的检测，他们目前的首要目标是凝血酶。
Researchers say the technology could be adapted to detect a number of different proteins, but they are focusing first on thrombin.
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