目的建立以凝胶法检查盐酸纳洛酮注射液细菌内毒素的方法。
OBJECTIVE to establish a method for assaying bacterial endotoxins in naloxone hydrochloride injection.
采用高效液相色谱法定量测定盐酸纳洛酮注射液中纳洛酮的含量。
HPLC method was used in the quantitative analysis of naloxone hydrochloride injectiOn.
但由于该药肝脏首过效应严重，口服无效，目前国内外临床上供应用的盐酸纳洛酮的剂型为注射液和舌下片。
Because of a serious liver first-pass effect, the dosage forms of Naloxone Hydrochloride is mainly used on domestic and aboard clinical practice in the forms of injection and sublingual tablet.
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