β2亚家族也称CD18抗原,因白细胞上均有1个或多个β2整合素故称白细胞整合素(leukocyte integrin)。包括3类糖蛋白:①淋巴细胞功能相关抗原-1(LFA-1):即CDⅡa/CD18,是白细胞上的粘附受体,参与白细胞与内皮细胞的粘附过程,能...
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牛白细胞粘附缺陷病(BLAD)是一种常染色体单基因隐性遗传疾病,病因为白细胞表面整合素cd 18亚单位基因突变所致。
Bovine leukocyte adhesion deficiency (BLAD) is autosomal recessive disease. The pathogeny of BLAD is genic mutation of CD18-integrins on the leukocyte.
阻断整合素介导的白细胞黏附(尽管在实验模型中是有裨益的)在治疗人类的炎症性疾病上所获得的成功是有限的。
Blocking integrin-mediated leukocyte adhesion, although beneficial in experimental models, has had limited success in treating inflammatory diseases in humans.
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