The proteins of NDV combine with part or whole cell membranes,which repress tumor cells metabolism and enhance the immunogenicity of the tumor cell. This mechanism is associated with Oncolysis.
NDV对肿瘤细胞杀伤作用的机制,国内外主要有3种观点:①NDV直接作用于瘤细胞诱导细胞凋亡;②NDV促进宿主产生细胞因子;③NDV蛋白质与瘤细胞部分或整个细胞膜结合,抑制瘤细胞代谢,增强瘤细胞免疫原性等,此机制与瘤细胞溶解效应有关。
参考来源 - 人用新城疫病毒抗肿瘤疫苗候选株的初步研制·2,447,543篇论文数据，部分数据来源于NoteExpress
目的：观察人胶质瘤细胞的体外侵袭能力及对胶原的溶解作用。
Objective To investigate the invasion ability and collagenolytic activity of human glioma cells in vitro.
瘤细胞能产生毒素或溶解性物质，使周围组织失去抵抗入侵的能力，恶性程度越高，特征越明显。
Tumor cells can produce toxins or soluble substances, so that the surrounding tissue lose the ability to resist the invasion, the higher degree of malignancy, the features more obviously.
目的：观察人胶质瘤细胞的体外侵袭能力及对胶原的溶解作用。
To investigate the invasion ability and collagenolytic activity of human glioma cells in vitro.
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