痛切，指悲痛；极其恳切；悲痛哀切；犹言有切肤之痛。见宋·叶适 《忠翊郎武学博士蔡君墓志铭》：“畏利欲如痛切，义理所集，趋前就之。”
她跪在一张椅子跟前，开始认真痛切地哭起来。
She dropped down on her knees by a chair, and set to weeping in serious earnest.
他终于痛切地认识到他犯了如此严重的错误。
Finally it came home sharply to him that he made such a serious mistake.
他的反感是如此痛切而敏锐，以致任何他可能看到或听到希刺克厉夫的地方他决不涉足。
So deep and sensitive was his aversion, that he refrained from going anywhere where he was likely to see or hear of Heathcliff.
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