结论SP通过调控成纤维细胞凋亡相关基因的表达参与病理性瘢痕形成，该作用由SP受体介导。

Conclusion SP may play an important role in the formation of pathological scars by modulating the expression of apoptosis-associated genes, which is mediated by SP receptor.

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结论：有效的病损内处置仍应作为此类邻膝关节骨巨细胞瘤的首选治疗方法，即使诊断时伴有病理性骨折者亦然。

Conclusion: an effective intralesional procedure should be the method of first choice for management of these giant cell tumors close to the knee, even with pathological fracture at diagnosis.

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细胞凋亡可被多种生理性、病理性及其它因素所诱发，它的发生过程可分为启始阶段、效应阶段和降解阶段。

Apoptosis can be induced by physiological, pathological and other factors, and there are initiation phase, effector phase and degradation phase during the course of its occurrence.

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