治疗期间出现耐药菌株会大大增加临床疗效不佳，包括死亡的风险。
The emergence of resistant strains during therapy greatly increases the risk of a poor clinical outcome, including death.
有些研究表明增加或者转到谈话疗法十分有益，但是换药或者加药，疗效却不甚明显。
Others showed that adding or switching to talk therapy was beneficial, but not any more so than changing a patient's prescription or having the patient take additional drugs.
“恢复或增加对大剂量尼古丁的厌恶或许可以完成这些措施，提高治疗效果，或者取代它们，”Lindstrom说。
"Restoring or increasing the aversion to high doses of nicotine may complement these approaches and increase their efficacy, or replace them," Lindstrom said.
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