但是，随着抗生素的广泛应用，特别是持续、不当使用，在临床上出现了严重的耐药问题，耐药性产生的直接后果是严重影响临床疗效，甚至导致治疗失败。

With the extensive use of the antibiotics, especially abuse, the serious problem of bacterial resistance has happened in clinic, which results in a decrease in curative effect, and even no effect.

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