是一类具有复制能力的肿瘤杀伤型病毒,世界上最早出现溶瘤病毒的报道,是由于当时发现一名子宫颈癌患者在感染狂犬病病毒后,肿瘤随之消退。
溶瘤病毒领域是一个正在成长的治疗癌症的领域。
The field of oncolytic viruses is a growing area in identifying new therapies for treating cancer.
相比之下,溶瘤病毒就可以复制传播,理论上可以到达更多的肿瘤细胞。
In comparison, oncolytic viruses can replicate and spread and theoretically can efficiently reach more tumor cells.
文章简要综述了溶瘤病毒肿瘤治疗的靶向性、杀伤性、安全性和疗效监测。
In this review, tumor targeting, killing efficiency, safety and the evaluation of oncolytic viruses therapy are discussed.
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