接枝PEG的量对引起的内含体破裂并释放DNA的质子海绵效应不会产生明显影响。
The degree of PEGylation had no obvious influence on the disruption of endosomal compartments and DNA releasing from endosomes via the proton sponge mechanism.
结论 脑干海绵状血管瘤表现为进行性神经功能缺失、具有占位效应、接近脑干表面者可考虑手术治疗；
Conclusion When the patients with brainstem cavernous malformation exhibited progressive neural function deficits and mass effect, it should be considered as good candidates for surgical therapy.
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