ATF: Activating Transcription Factor 活化转录因子 ATF: Automatic Track Finding 自动寻迹 ATF: Automatic Track Following 自动跟踪 ..
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热休克因子1 (HSF1)是一种转录因子，在正常时不活化，应激时活化而具有反式激活能力。
As a transcription factor, heat shock transcription factor 1 (HSF1) is activated during stress and subsequently trans-activate its downstream factors.
在正常生长条件下，热激因子处于钝化的单体状态，而当热激时，热激因子形成三聚体并与DNA结合，同时通过转录激活域的活化而激活热激基因的表达。
HSF is present in a latent state under normal conditions; it is activated upon heat stress by induction of trimerization, high affinity binding to DNA and transcriptional activity.
大多数雄激素非依赖性前列腺癌均高表达AR和核受体辅活化子、如转录中间因子2（TIF-2），ARA24、PIAS、类固醇受体辅活化子-1（SRC-1）等有力地支持了这个假说。
The "superactive AR"hypothesis was supported by the fact that the majority of AIPC expresses high level of AR and nuclear receptor(NR) coactivators, such as TIF-2, ARA24, PIAS, SRC-1.
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