格拉司琼(Granisetron)是一种高选择性的5-HT3受体拮抗剂,对因放疗、化疗及手术引起的恶心和呕吐具有良好的预防和治疗作用。放疗、化疗及外科手术等因素可引起肠嗜铬细胞释放5-HT,5-HT可激活中枢或迷走神经的5-HT3受体而引起呕吐反射。本品控制恶心和呕吐的机制,是通过拮抗中枢化学感受区及外周迷走神经末梢的5-HT3受体,从而抑制恶心、呕吐的发生。本品选择性高,无锥体外系反应、过度镇静等不良反应。
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名称】 通用名称:格拉司琼 英文名称:Granisetron Hydrochloride Capsules 汉语拼音:Yansuan Gelasiqiong Jiaonang 【成份】本品主要成分是盐酸格拉司琼 【适应症】止吐药。用于:①细胞毒性药物化疗和放射治疗引
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盐酸格拉司琼 Granisetron Hydrochloride ; Granisetron HCl ; US DMF ; GranisetronHy
盐酸格拉司琼注射液 Granisetron Hydrochloride Injection
盐酸格拉司琼胶囊 Granisetron Hydrochloride Capsules
盐酸格拉司琼片 Granisetron Hydrochloride Tablets
注射用盐酸格拉司琼 Granisetron Hydrochloride for Injection
盐酸格拉司琼分散片 Granisetron Hydrocholoride Dispersible Tablets
7-羟基格拉司琼 Hydroxy granisetron
羟基格拉司琼 Hydroxy granisetron
盐酸格拉司琼杂质A Granisetron Related Compound
Results:The calibration curve was linear within a concentration range of 0.501-20.04 ng/ml,with the limit of quantification being 0.501 ng/ml. The main pharmacokinetic parameters of granisetron in the volunteers were as following:Cmax(6.93±1.90)ng/ml,tmax(1.35±0.29)h,t1/2(5.59±1.87)h,MRT(8.05±1.84)h,Cl/F(54.23±16.08)L/h,AUC0-24(36.61± 8.87)ng·h·ml-1 and AUC0-∞(39.32±9.36)ng·h·ml-1.
结果:单剂量口服2mg盐酸格拉司琼胶囊后,主要的药代动力学参数Cmax、tmax、t1/2、MRT、Cl/F、AUC0-24和AUC0-∞分别为(6.93±1.90)ng/ml,(1.35±0.29)h,(5.59±1.87)h,(8.05±1.84)h,(54.23±16.08)L/h,(36.61±8.87)ng·h·ml-1和(39.32±9.36)ng·h·ml-1。
参考来源 - 盐酸格拉司琼胶囊健康人体药代动力学研究·2,447,543篇论文数据,部分数据来源于NoteExpress
目的观察盐酸格拉司琼止吐效果和毒性。
Objective To study the antiemetic effect and toxicity of granisetron.
对照组化疗期间常规应用格拉司琼药物治疗。
The patients in the control group were treated routinely with Granisetron Hydrocloride Injection during chemotherapy.
格拉司琼可作为预防化疗引起的恶心、呕吐的优选药物。
Granisetron is a good choice drug in the prevention of chemotherapy induced nausea and vomiting.
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