目前临床使用的药物有罗格列酮（Rosiglitazone，RSG）和匹格列酮（Pioglitazone，PIO），统称 格列酮类 （ Glitazones ）。TZDs为过氧化物酶体增生激活受体g（PPARg）的高度抉择性及强力的冲动剂。
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这两个都为格列酮类的合理应用提供空间，我不认为他们之间存在矛盾。
Both make room for the use of glitazones in appropriate circumstances so I do not think they contradict each other.
在正确的方向显示积极的数据，所以我要说匹格列酮类药物可能是安全的。
"The PROACTIVE data went in the right direction, so I would say pioglitazone was probably safe," he said.
一项新的研究显示患有糖尿病的绝经妇女在服用噻唑烷二酮类药物，包括匹格列酮与罗格列酮时，会增加骨折的危险。
A new study has revealed that postmenopausal women with diabetes taking thiazolidinediones (TZDS), including rosiglitazone and pioglitazone, may be at increased risk for fractures.
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