多种细胞机制功能障碍将导致染色体不稳定性，包括染色体分离、DNA损伤反应、细胞周期检查点、端粒功能等。
Several factors, such as defects in chromosome segregation and DNA damage response, failure of cell cycle checkpoint, telomere dysfunction, may cause chromosomal instability.
中心体作为细胞的主要微管组织中心，在细胞周期过程中建立两极纺锤体，调节细胞有丝分裂，从而对维持染色体的稳定起着重要的作用。
The centrosome, the major microtubule organizing center regulates cell division through forming bipolar mitotic spindles and plays an essential role in the maintenance of chromosomal stability.
该所的科学范围涉及细胞周期，细胞分化，肿瘤形成，染色体生物学，神经元引导，和干细胞生物学等多个领域。
Its scope of the science spans such diverse areas as cell cycle progression, cell differentiation, oncogenesis, chromosome biology, neuronal guidance and stem cell biology.
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