因为男性只有一条从母亲那里遗传来的X染色体,因此他们的TEX11基因只有一个拷贝,理论上来说,TEX11基因的任何突变都可以导致不育。
Because men have only one X chromosome that they inherit from their mother and thus only one copy of the TEX11 gene, any mutation could theoretically lead to sterility.
几十年来,传统的理论认为X染色体与减数分裂以及男性不育无关,因为在男性减数分裂过程中X染色体被沉默掉了。
For decades, conventional wisdom stated that the X chromosome had little to do with meiosis or infertility because the X chromosome is silenced during male meiosis.
染色体平衡易位携带者由于自身染色体是平衡的因此没有异常表型,但将导致不育、流产、死胎、畸胎、胎儿宫内和出生后生长缺陷。
Although the carriers of chromosomal balanced translocation have normal phenotypes they would lead to infertility, abortion of fetus, malformation of fetus and congenital defects after born.
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