但什么是这些药物的最佳剂量，最大耐受剂量，最大限度抑制目标的最小剂量？
The maximum tolerated dose? The minimum dose that leads to maximum inhibition of the target?
本文研究的是药物最大耐受剂量（MTD）的识别方法。
The paper investigates designs of dose-finding trials, the purpose of which is to determine the maximum tolerated dose (MTD).
本文研究的是在第一阶段临床试验中，寻找两种制剂混合而成药物的最大耐受剂量的方法。
In this paper, the author want to probe the method how to find one or more acceptable drug dose combinations of two agents used together in a Phase I clinical trial.
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