我们提出了肺结核分支杆菌细胞色素P 450 CYP121与三氮唑类药物氟康唑的复合物的晶体结构,揭示了唑类与亚铁血红素新的结合模式。
We present here the crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121 in complex with the triazole drug fluconazole, revealing a new azole heme ligation mode.
对B27与抗原肽复合物晶体结构的研究表明,B27与抗原肽结合具有特异性和可塑性,不同亚型具有不同的结合特点。
Research about crystal structure of HLA-B27-peptide complexes suggested the specificity and plasticity of peptide-binding and subtypes dependent binding features.
利用晶体X射线衍射的方法获得药物与靶标复合物的结构,为药物设计提供最直接有力的依据。
The structures of drug-target complexes obtained by X-ray crystallography provide direct and convictive evidences for drug design.
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