背景：肿瘤细胞的染色体数目畸变是肿瘤细胞的特征性改变之一。
Background: Chromosomal number abnormality is one of the characteristic changes in tumor cells.
有染色体数目畸变的恶性肿瘤患者，无论临床转移或病理分级恶性程度都较高。
In the patients with malignant neoplasms, exitsmce of chromosome aberration predicted highly malignant in terms of cither clinical metastasis or pathological grading.
方法测定2 0只豚鼠听性脑干反应（ABR）阈和畸变产物耳声发射（DPOAE）振幅，观察耳蜗毛细胞静纤毛变异形态，计数变异的毛细胞数目。
Methods Auditory brainstem response(ABR)and otoacoustic emission of distortion products(DPOAE)were assayed to 20 guinea pigs, then variant hair cells were observed and counted.
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