...同传统使用『循理 式的药物设计(rational drug design)』、『定量的构效关系(quantitative structure-activity relationships,QSAR)』与『资讯学(informatics)』进行先导化合物最佳化;而『组合式 合成 筛选 设计 先导化合..
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...各样本对大鼠的活血化瘀(出血时间)药效为指标,采用GA-MLR方法构建定量谱-效关系(quantitative spectrum-activity relationship,QSAR)模型,并将模型初步应用于外部样本的药效预测。
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首先基于PHⅡ-7的定量结构-药效关系(Quantitative Structure-Activity Relationship,QSAR),通过有机化学合成方法在非活性位点1-N位引入氨烷基侧链,得到PHⅡ-7氨烷基侧链衍生物;再次同样运...
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定量构效关系 QSAR ; Quantitative Structure-Activity Relationship ; Quantitative Structure-Property Relationship
构效关系 Structure-activity relationship ; QSAR ; Structure-function relationship ; structure-response relationship
量效关系 Dose-effect relationship ; dose-response relationship ; Dose-effect relation
时效关系 time-effect relationship ; time-response relationship
全息定量构效关系 HQSAR
时-效关系 Time-effect relationship
化学信息学及构效关系 Cheminformatics & QSAR
结论迷宫学习模型实验存在特殊类型的时反应量效关系。
Conclusion There is a special type of timed dose-response relationship in maze test of learning and memory model.
为了解其催化水解梭曼的机制,需对其进行构效关系研究。
To know the abzyme mechanism of soman hydrolysis, the structure-activity relationship of soman and abzyme was studied.
该方法为建立定量构效关系(QSAR)模型奠定了生物学检测基础。
The method established the biological foundation for building quantitative structure-activity relationship (QSAR) model.
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