连接肌膜电兴奋和肌丝滑行收缩的过程。 肌细胞动作电位-电兴奋通过横管传入肌细胞深处-三联管处信息传递【胞外钙离子进入细胞触发肌浆网释放更多的钙离子-细肌丝上肌钙蛋白结合钙离子后使原肌凝蛋白变构并解除它对肌纤蛋白与粗肌丝肌凝蛋白横桥结合的阻碍作用-结合后产生ATP酶活性并利用分解ATP获取的能量使横桥摆动导致细肌丝向粗肌丝之间滑行-肌小节、肌原纤维、肌细胞乃至整条肌肉长度缩短(肌肉收缩)】-肌浆网上钙泵回收钙离子-肌肉舒张。
取右心室束状肌分析其心肌兴奋-收缩耦联的变化。
Trabeculae from the right ventricle of mice were dissected for assessment of changes in excitation-contraction coupling.
心肌钙信号在心肌细胞兴奋-收缩耦联中起着重要作用,它和心房颤动发生机制有关。
Cardiac calcium signal plays an important role in excitation-contraction coupling. It is also associated with developing mechanisms of atrial fibrillation.
别嘌呤醇的强心作用在于它不但能够改善心衰心肌钙分布的不平衡状态,而且能够增加肌丝蛋白对钙的敏感性,改善异常的兴奋收缩耦联。
Allopurinol can enhance cardiac function by improving unbalanced distribution of calcium, increase the sensitivity of myofilaments to calcium and improving abnormal excitation contraction coupling.
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