The release rate and accumulation in in vitro percutaneous permeability of amorolfine were determined by Franz diffusion cells. The distribution of rhodamine B(probe drug) in the rat skin was observed under a confocal laser scanning microscope.
方法:采用注入法制备盐酸阿莫罗芬乙醇脂质体并测定其体外释放百分率;采用Franz扩散池进行离体皮肤渗透实验,测定盐酸阿莫罗芬在接受液内的累积渗透百分数;在激光共聚焦显微镜下观察不同罗丹明B(探针药物)制剂在小鼠皮肤内分布的情况。
参考来源 - 盐酸阿莫罗芬乙醇脂质体的制备及评价·2,447,543篇论文数据，部分数据来源于NoteExpress
两组间探针药物咪哒唑仑代谢率及CYP3A4蛋白表达无明显差异。
The metabolic rate of midazolam and the protein expression of CYP3A4 showed no difference between treated and control groups.
目的建立以硝苯地平为探针药物测定大鼠和犬肝微粒体活性的HPLC/MS。
OBJECTIVE To establish a HPLC/MS method to determine microsomes activity in vitro using nifedipine as a probe drug.
方法：综述近几年具遗传多态性代谢酶的探针药物、代谢分型方法以及影响因素。
METHOD:The probe drugs of drug metabolism, methods of phenotype and related factors were reviewed.
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