“人类缺失依拉鲁肽作用的C细胞受体,”他断言。
"Humans lack the C-cell receptors that liraglutide ACTS on," he asserted.
依拉鲁肽刺激啮齿类动物的C细胞使其降钙素生成增加并有部分实验动物发生肿瘤,但未观察到有人类发生此类严重副作用。
Liraglutide stimulates C-cells in rodents, causing an increase in calcitonin and there were few cases of cancer in these animals, but there were none in nonhuman primates nor in any humans.
两种药使用中报告频率最多的不良反应是呕吐,依拉鲁肽组相比依克那肽组持续呕吐的发生要稍轻些。
Nausea was the most commonly reported adverse event with both agents, with slightly less persistent nausea in the liraglutide group than in the exenatide group.
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