目的：对炭疽毒素保护性抗原（PA）的不同结构域进行了缺失突变，以期找到免疫原性降低而功能变化不大的PA蛋白突变体。
Objective:To find protective antigen(PA) defective mutants of anthrax toxin with the same function as PA but with low immunogenicity, different domains of PA were mutated.
该突变体的溶栓活性没有明显变化，而突变体的抗原性显著降低。
Although there is no significant change with thrombolytic activity of the mutant, antigenicity of the mutant decreases significantly.
本发明属突变或遗传工程领域，本发明公开了一种葡激酶的低抗原性突变体的制备方法及用途。
This invention belongs to mutation or genetic engineering field, which discloses a preparation of low antigen mutation of staphylokinase and its usage.
应用推荐