We also attempt other method, which is using Morin conversion to get ring enlargement product, we find bad reproductivity, which is not conducive to productivity.
同时尝试了其他合成方法,用Morin转换来获得扩环产物,发现重现性差,不利于工业化生产。
参考来源 - GCLE的合成工艺研究·2,447,543篇论文数据，部分数据来源于NoteExpress
评述了各种扩环催化剂的催化特点。
The catalytic specialities of ring enlarging catalysts were also discussed briefly.
方法以3-溴苯胺为起始原料，经过成环、氧化、扩环等反应得到目标产物。
METHODS Bretazenil was synthesized from 3-bromoaniline by cyclization, oxidation and ring-enlargement reaction, etc.
在乙腈溶剂中，碳酸钾存在下，双咪唑啉和1，2-二溴乙烷进行扩环反应，得到环状中间体一溴盐，产率78。
The reaction of bis-imidazoline with 1,2-dibromoethane and potassium carbonate in acetonitrile provided monobromide salt with a yield of 78.
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