目的对不同房室延迟DDD起搏患者进行血流动力学评价，探讨DDD起搏最佳房室延迟的设置方法。

Objective To investigate the optimal AV delay by means of evaluation of the hemodynamics at different AV delay in patients with a DDD pacemaker implanted.

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基于改进的单纯形算法和残数法，对药物动力学房室模型中的有关参数计算进行了研究。

By using improved simplex method and residuals method, a calculation based on the parameters of compartment model of pharmacokinetics is presented.

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PCNONLIN程序进行药物动力学房室模型数据拟合和参数计算；

The modelling data were performed with a compartment pharmacokinetic modelling program (PCNONLIN).

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