我必须指出新药的试验很昂贵，而且你永远不能保证成功。

I must point out that trials of new medicine are expensive and you can never guarantee success.

youdao

你必须分清轻重缓急，所以要指出主要的问题，然后通过与理论的联系分析每一个问题。

You have to prioritise, so indicate the main problems, and then you analyse each one by connecting it with a theory .

youdao

必须着重指出的是，我们必须重视环保。

It must be stressed that we should attach great importance to environmental protection.

youdao

But I need to point out that there's another disadvantage that the fission case raises for the soul theory.

但我必须要指出，灵魂理论的裂变案例,其实还有一个缺点。

耶鲁公开课 - 死亡课程节选

And robots, the objection goes, are programmed; they necessarily follow their program.

而且这一反驳指出,机器人是被编程的,机器人必须遵照程序做事

耶鲁公开课 - 死亡课程节选