Background and ObjectiveDonor killer cell immunoglobulin-like receptors （KIR） cluster and recipient human leukocyte antigen （HLA） mismatching induce NK cell alloreactivity in allo-hematopoietic stem cell transplantation.
背景与目的供者杀伤细胞免疫球蛋白样受体(KIR)基因簇和受者人白细胞抗原(HLA)不匹配诱导的NK细胞异体反应可改善异基因造血干细胞移植的治疗效果。
参考来源 - KIR基因簇KIR3DL1、KIR2DL1、KIR2DL2/3多态性研究·2,447,543篇论文数据，部分数据来源于NoteExpress
我想有关同种异体反应性基础的这些发现拓宽了我们对于该过程的理解。
I think these findings about the basis of alloreactivity expand our understanding of this process.
该研究的目的在于明确是否同种异体反应性非CD4依赖的CD8+T细胞通过外生性刺激能够能够导致长期移植物的丢失。
This study was performed to determine if activation of alloreactive CD4-independent, CD8+ T cells, by exogenous stimuli, can precipitate late loss of islet allografts.
Christopher Garcia领衔的科研小组揭示了T细胞表面受体结构为何能双重识别，该现象也称为同种异体反应性。
Christopher Garcia have established how the structure of receptors on the surface of t cells enables this dual recognition, a phenomenon known as alloreactivity.
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