方法：汇总分析1998 ~ 2006年国内文献报道的有关局部用药引起的不良反应文献。
METHODS: Domestic literature regarding the ADRs caused by local application of drugs published during 1998 ~ 2006 was reviewed retrospectively.
前言： 目的：用组织化学和动物实验方法观察盐酸四环素根管给药后局部组织的反应，探讨其作为根管治疗术用药的前景。
AIM:To observe the reaction of the topical tissue by using tetracycline-HCI as a root canal treatment and discuss the future of tetracycline in that treatment.
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