material breach 实质性违反; 严重违约, 实质违约; 重大违约 anticipatory breach of contract 先行违反合约; 预期违约 .
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如果一方对合同任何条款有实质性违反，且在收到另一方书面通知30日内未予改正。
If any party to the contract have a substantive violation of the terms and the receipt of the other party notice in writing within 30 days was not correct.
对其它九个登记病人数高的地方的检查显示了严重的违反实验指导，提起了人们对这个实验的整个真实性的实质性关注。
Inspections of nine other sites enrolling high Numbers of patients revealed serious violations of trial conduct, raising substantial concerns about the overall integrity of the study.
某些金融公司违反重要的反欺诈法规，因为屡屡违犯者并没有受到实质性惩治。
Some financial firms violate major anti-fraud laws because there's no real penalty for being a repeat offender.
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