目的制备齐多夫定片并探讨其质量控制方法。
Objective to develop zidovudine tablets and to study its quality-control method.
齐多夫定会竞争性抑制司他夫定的磷酸酰化,因此禁止与齐多夫定联合用药。
Zidovudine may competitively inhibit the intracellular phosphorylation of stavudine. Therefore, use of zidovudine in combination with Stavudine is not recommended.
方法以湿法制粒工艺制备齐多夫定片,采用高效液相色谱法对其进行含量测定。
Methods to develop zidovudine tablets with the technology of wet method pelletization and to determine the content of zidovudine tablets by HPLC.
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