目的对天然抗角蛋白单克隆抗体3B4的多反应性进行鉴定，并探讨其分子基础。
Objective To identify the polyreactivity of a monoclonal natural anti-keratin autoantibody 3B4 and to analyze its possible molecular mechanism.
背景和目的：慢性HCV感染过程中能够产生广泛的中和性抗体（nAbs）和多特异性的T细胞反应，但仍然不能够清除病毒。
Background & Aims: Broadly reactive neutralizing antibodies (nAbs) and multispecific T-cell responses are generated during chronic hepatitis C virus (HCV) infection and yet fail to clear the virus.
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