而临床一线药物塞莱昔布(Celecoxib)对COX-1的IC50值大于10uM,对COX-2的IC50值为0.050uM。由此可见,该化合物是COX-2有效的选择性抑制剂。
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The tumor can be touched in each mice injected three to five days later. PG group began to theraping with celecoxib (40mg·kg-1·d-1).
3-5后各荷瘤小鼠皮下均可触及肿瘤结节,预防组开始用药每天给予塞莱昔布(40mg·kg-1·d-1)。
参考来源 - 选择性COX·2,447,543篇论文数据,部分数据来源于NoteExpress
目的探讨塞莱昔布对家族性结肠息肉病病人术后的肠息肉的防治作用。
Objective To explore the preventive effect of Celecoxib on recurrence of the familial polyposis coli (FPC) after operation.
目的:探讨三氧化二砷、塞莱昔布对HCCLM_3肝癌细胞生长、粘附、运动、侵袭及其复发、转移相关基因表达的影响。
Objective: Discuss the influence of As_2O_3 and Celecoxib on HCCLM_3 hepatoma cell growth, adhesion, movement, invasion and expression of relative gene with hepatoma recurrence and metastasis.
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