基础毒性（basic toxicity）是指外源化学物质在一定剂量、一定接触时间、一定接触方式下对实验动物产生综合毒效应的能力，亦称为一般毒性。
这是因为一旦知道药效基因，药物化学家就可以修饰它，在保持药效的基础上减少毒性。
This is because once a pharmacophore is known, medicinal chemists can modify it to reduce toxicity while maintaining (or enhancing) potency.
病理基础是预处理毒性引起肝脏内肝小叶3区内的血窦内皮细胞以及肝细胞损害所致。
The basis of pathology of vod is thought resulting from injury of hepatocytes and endodermis cells surrounding the central veins in zone3of the liver acinus by regimen-related toxicity.
结论目前黄药子针对功效、物质基础和毒性的研究都是孤立的，彼此之间缺少关联性。
Conclusion Recent studies on its function, material base and toxicity were isolated that lack of relative study.
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