通过比较老烟民与非烟民的肺活体组织，研究人员发现372个基因的表现度(译者注：基因的表现度描述一个组织中的一个基因产生作用的程度)由烟草烟尘触发。

By comparing the lung biopsies from regular smokers to those from nonsmokers, the researchers identified 372 genes whose expression was triggered by tobacco smoke.

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他们写到，“这些基因表现度的变化貌似是诊断肺部疾病的呼吸道上皮细胞最早期生理异常改变”。

“These changes in gene expression are likely the earliest biologic abnormalities in the small airway epithelium that lead to clinically detectable lung disease,” they wrote.

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他们写到，“这些基因表现度的变化貌似是诊断肺部疾病的呼吸道上皮细胞最早期生理异常改变”。

"These changes in gene expression are likely the earliest biologic abnormalities in the small airway epithelium that lead to clinically detectable lung disease," they wrote.

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