方法以评价基因-环境交互作用的乳腺癌病因学研究为实例，介绍反向配比的设计方法和统计分析方法。
Methods Through elaboration of the study about gene-environment interactions in the etiology of breast cancer, methodology regarding counter-matching design and statistic methods was introduced.
结论ALDH2基因多态性与胃癌易感性有关，并与环境暴露有一定的交互作用。
Conclusion The genetic polymorphisms of ALDH2 might contribute to gastric cancer susceptibility and interact with environmental exposure.
广义线性模型分析提示CXCR4和CCR3基因与环境交互作用与SLE的发病不存在关联。
Result of generalized linear model showed that interaction between CXCR4 and CCR3 gene and environmental was irrelevant to pathogenic of SLE.
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