The metabolic studies of quinoxalines in different species liver microsomes show that the N→O group reduction and hydroxlation are the same two metabolic pathways of quinoxalines. Moreover, the toxicities of quinoxlaines are related to the N→O group reduction.
喹恶啉类共同的主要代谢途径是N→O基团还原,其次是羟化,且其毒性与其N→O基团还原有关。
参考来源 - 喹恶啉类在大鼠、猪和鸡的比较代谢研究·2,447,543篇论文数据,部分数据来源于NoteExpress
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