色氨酸是一种不稳定的氨基酸，高于200 o C处理时，会产生强致突变作用的物质咔啉（Carboline）。从热解的色氨酸中可分离出α-咔啉（R 1 =NH 2 .
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Thus,we constructed the basic structure of CSIs,and synthesized three series of novel carboline derivatives. The total 112 compounds were tested for their cytotoxic activities in vitro against several human tumor cell lines.
根据这一设计思想,共合成了三类112个全新的咔啉类衍生物,并对其进行了体外抗肿瘤活性筛选。
参考来源 - 咔啉及其类似物的设计、合成及抗肿瘤活性研究·2,447,543篇论文数据，部分数据来源于NoteExpress
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