同义突变是DNA 片段中有时某个碱基对的突变并不改变所编码的氨基酸。其原因在于该位置的密码子 突变前后为简并密码子。如:CTA与CTG 均编码亮氨酸,若A突变为G则该变异为同义突变。
除同义突变外,在 MYH9 基因的外显子和弗兰克区域未检测到致病突变。
No pathogenic mutation was detected in the exon and franking regions of MYH9 gene except a synonymous mutation.
MYH9基因40个外显子和侧翼区未见致病突变(除25号外显子发生一同义突变,突变类型为A1143A)。
No pathogenic mutation was detected in the exon and franking regions of MYH9 gene except a synonymous mutation(A1143A) in the exon 25.
他们在32个基因的52个体细胞非同义突变中找到了2个参与组蛋白修饰 (CREBBP 与 CTCF)的基因。
Of the 52 somatic nonsynonymous mutations found in 32 genes they found two genes involved in histone modification (CREBBP and CTCF).
应用推荐