叶酸是由喋啶，对氨基苯甲酸和谷氨酸残基组成的一种水溶性B族维生素，亦称为维生素BC或维生素M，为机体细胞生长和繁殖所必需的物质，帮助蛋白质的代谢，并与维生素B12共同促进红细胞的生成和成熟，是制造红血球不可缺少的物质。
Folate metabolism is thought to play an important role in lung cancer through its involvement in both DNA methylation and nucleotide synthesis.
叶酸代谢在肺癌发生过程中占有重要的地位,因为叶酸的代谢同时影响了DNA与核苷酸的合成。
参考来源 - 5·2,447,543篇论文数据，部分数据来源于NoteExpress
已经证明，叶酸代谢也需要钾。
遗传因素中包括细胞增殖因子、转录因子及影响叶酸代谢的关键酶的基因。
The genetic factors include cell growth factors, transformation factors and key enzymic genes involved in folate metabolism.
结论：PM X能诱导NTD的发生，其机制可能是因为PMX阻断了叶酸代谢通路并导致神经上皮细胞的增殖抑制和过度凋亡。
Conclusion: NTD embryos were induced by PMX, the mechanism of which might be PMX inhibited folate metabolism pathway and led to decreased cellular proliferation and excessive cellular apoptosis.
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