有些基因的一个mRNA前体通过不同的剪接方式(选择不同的剪接位点)产生不同的mRNA剪接异构体,这一过程称为可变剪接(或选择性剪接, alternative splicing) 。可变剪接是调节基因表达和产生蛋白质组多样性的重要机制, 是导致真核生物基因和蛋白质数量较大差异的重要原因
可变剪接(alternative splicing,AS)是在前体mRNA中选择不同的剪接位点后进行多种方式剪接,产生 多种成熟的mRNA和复杂多样的蛋白质,...
基于606个网页-相关网页
In summary, the results suggest that THAP11 can prevent tumor invasion and metastasis by repressing the alternative splicing of CD44, and also the interaction with PCBP1 plays an important role in exhibiting its biological effect.
以上结果表明THAP11可通过抑制CD44可变剪接进而抑制肝癌侵袭、转移,该蛋白与PCBP1的相互作用可能是其发挥作用的重要方式。
参考来源 - THAP11与PCBP1相互作用的分子机制及其生物学功能研究The different outcome protein activity of tra-1 gene depends on the alternative splice of mRNA processing, which governs the number of zinc fingers in the resulting TRA-1 protein.
tra-1基因通过可变剪接加工来改变mRNA的3’末端,进而改变产物蛋白不同的活性。
参考来源 - 线虫(C.elegans)traIt is believed that regulation of pre-mRNA alternative splicing is very complex.
基因的可变剪接调节机制十分复杂。
参考来源 - 血管内皮细胞中缺氧相关基因的可变剪接研究·2,447,543篇论文数据,部分数据来源于NoteExpress
此外,转录延伸速率也与可变剪接相关。
Moreover, the rate of transcription elongation has been linked to alternative splicing.
可变剪接在发育、分化和癌症等过程中发挥着非常重要的作用。
Alternative splicing plays an important role in processes such as development, differentiation and cancer.
研究基因的可变剪接对理解真核生物基因调控具有十分重要的意义。
Studying alternative splicing mechanism is of great significance to understanding eukaryote gene regulation.
应用推荐