Another question in oral vaccine study is the quantity of antigen arriving at the intestines is too low to raise the intestinal mucosal immunization.
如果口服疫苗抗原没有经过特殊的处理而直接进行口服免疫时,能够有效到达肠道并激起肠道内淋巴系统特异反应的抗原量太低,也不能有效诱导肠道内的免疫反应。
参考来源 - 肠出血性大肠杆菌O157：H7植物疫苗的研究Salmonella choleraesuis C500 strain can be used as the attenuated vaccine preventpiglet paratyphoid, also can act as live vector of other DNA vaccines, oral immunization,can induce immune response to specific antigens carryed by it.
猪霍乱沙门氏菌C500株不仅可以作为预防猪沙门氏菌病的活疫苗，还可作为载体运送其他DNA疫苗，并通过口服免疫诱导产生针对特定抗原的各种免疫应答。
参考来源 - 猪霍乱沙门氏菌携带的含APP apxIIA基因的双启动子表达载体pEPR·2,447,543篇论文数据，部分数据来源于NoteExpress
目的从细胞和分子水平探讨小鼠口服免疫幽门螺杆菌超声处理菌液后的粘膜免疫应答。
Objective To investigate the mucosal immune responses of mice induced by oral administration of Helicobacter pylori (Hp) sonicates.
对鲤鱼竖鳞病疫苗的安全性、免疫保护力和免疫效价进行了系统性的研究，并进行了口服免疫养殖应用实验。
A systematic research had been done on safety of vaccine against carp dropsy, immunological protection and valence, and an oral vaccination was carried out in fishery.
全菌灭活疫苗浸泡免疫、注射免疫和微囊化疫苗口服免疫的抗体滴度（凝集抗体效价）平均分别为1：19、1：190、1：62；
The average antibody titers(agglutination titer)of the Whole-cell vaccine immunization, injection immunization and microencapsulated vaccine oral immunization were respectively 1:19,1:190,1:62;
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